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Weight Loss and Endothelial Function in ObesityEndothelial dysfunction, a pathologic feature of obesity, predicts the occurrence of cardiovascular disease, and is felt to mediate the increased cardiovascular risk associated with a number of classical and non-classical risk factors. However, the pathogenesis of endothelial dysfunction in obesity remains uncertain. In this field, the major questions center on the relative roles of insulin resistance, fatty acids, or adipocyte-associated cytokines on endothelial function. For example, a number of groups have demonstrated the ability of acute increases in circulating non-esterified fatty acids to induce insulin resistance at both the cellular and whole-body levels. The observation that such interventions also induce vascular dysfunction has hinted at the mechanism of obesity-associated endothelial dysfunction, but many questions remain. For next page, click Affects of Weight Loss on Endothelial Function See also: 1. Weight
Loss and Endothelial Function in Obesity Short Articles About Obesity and Overweight
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