weight loss information
|
Endothelial Function & Weight Loss StudyAs presented in this issue of Diabetes Care, Bergholm et al. have undertaken a study of the effects of modest weight loss on endothelial function in obese women with a history of gestational diabetes. Subjects were randomly assigned to dietary intervention plus orlistat, or dietary intervention plus matched placebo. The primary end point was the effect of treatment on forearm vascular function, assessed using plethysmography and direct intra-arterial infusion of endothelium-dependent and endothelium-independent vasodilators. Both groups achieved comparable reductions in body weight (8 percent), with matched reductions in other anthropomorphic measures and in circulating fasting insulin levels. The timing to achieve target weight loss did not differ between groups, and a weight maintenance diet was instituted for 2-4 weeks in advance of the post-therapy measurements. Changes in circulating lipid levels were matched with two exceptions: the placebo group, but not the orlistat-treated group, had a modest reduction in triglyceride levels, and orlistat, but not placebo, was associated with a significant (but modest) reduction in LDL cholesterol. For next page, click Obesity Treatment Responses See also: 1. Weight
Loss and Endothelial Function in Obesity Short Articles About Obesity and Overweight
|
|
|
|
com