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Ephedra, Caffeine and Weight Loss Trial
Safety and Weight Control Benefits of Herbal Ma Huang and Kola Nut Supplements
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Ephedra, Caffeine & Weight Loss - Trial

Weight Loss Study Aim
To examine long-term safety and efficacy for weight loss of an herbal Ma Huang and Kola nut supplement (90/192 mg/day ephedrine alkaloids/caffeine).

Weight Loss Study Subjects
A total of 167 subjects randomized to placebo or herbal treatment at two outpatient weight control research units.

Weight Loss Study Measurements
Primary outcome measurements were changes in blood pressure, heart function and body weight. Secondary variables included body composition and metabolic changes.

Weight Loss Study Results
By last observation carried forward analysis, herbal vs. placebo treatment decreased body weight, body fat and LDL-cholesterol, and increased HDL-cholesterol. Herbal treatment produced small changes in blood pressure variables, and increased heart rate but cardiac arrhythmias were not increased. By self-report, dry mouth, heartburn, and insomnia were increased and diarrhea decreased. Irritability, nausea, chest pain and palpitations did not differ, nor did numbers of subjects who withdrew.

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