Respiratory Quotient & Weight Loss
Weight Loss Study Aim
To investigate the possible metabolic factors predisposing to weight gain
subsequent to the cessation of a rapid-weight-loss diet.
Weight Loss Study Method
Prospective, longitudinal, intervention study of a 2 MJ diet daily for
28 days in a metabolic ward followed by a 12-month outpatient follow-up
under a conventional, hypo caloric diet. Subjects
included 35 females and one male, all with morbid obesity defined by a
body mass index 35 kg/m2.
Weight Loss Study Measurements
VO2 and VCO2 measured by 30 min indirect calorimetry to calculate resting
energy expenditure and resting respiratory quotient at the beginning and
end of very-low-calorie diet; body composition assessed by hydrostatic
weighing on day 1; weight recorded on days 1 and 28 and at follow-up of
3, 6 and 12 months.
Weight Loss Study Results
From among all the variables considered, the resting respiratory quotient
measured on day 28, even adjusted for weight loss during hospitalisation,
was the only one that correlated significantly with the weight changes
recorded during follow-up.
Weight Loss Study Conclusion
Subjects who showed a respiratory quotient on day 28 in the lower range
were more able to maintain the weight-loss achieved with the very-low-calorie
diet while those in the higher range were less able to do so over the
follow-up period. Thus, an appropriately measured respiratory quotient
could prove useful in clinical practice as a prognostic marker of the
long-term effectiveness of low- and very-low-calorie diets used to induce
rapid weight loss.
Source: International Journal of Obesity
(1997)
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