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Weight Loss & Energy
Weight loss and changes in energy metabolism in massively obese adolescents.
Weight Loss Study Aim
To investigate the energy metabolism modifications induced by energy restriction
and weight loss in massively obese adolescents.
Weight Loss Study Subjects
Ten massively obese girls after 2-5 weeks on a low-energy diet and 4.5-11.5
months later, that is, after a substantial weight loss, and weight controls.
Weight Loss Study Measurements
Resting energy expenditure (REE) and carbohydrate-induced thermogenesis
(CIT) after a sucrose load (by indirect calorimetry), plasma glucose and
insulin before and after the sucrose load.
Weight Loss Study Results
After 2-5 weeks on a low-energy diet, REE was lower than the expected
value calculated from the regression equation of REE on fat free mass
in controls. After a 37±17 percent reduction in excess weight,
REE decreased and remained lower than the expected value. At the early
stages of weight loss, the area under the plasma glucose response curve
was negatively correlated with CIT and was higher in the six obese adolescents
with low CIT than in the four with normal CIT. After substantial weight
loss, the area under the plasma insulin response curve decreased by 32
percent, and both CIT and the area under the plasma glucose response curve
became similar in obese patients with low and normal CIT prior to weight
loss.
Weight Loss Study Conclusion
These results indicate that in massively obese adolescents, REE for fat-free
mass is decreased at the very beginning of the process of losing weight
and remains decreased as long as energy restriction and weight reduction
carry on. They also indicate that the impaired CIT sometimes observed
returns to normal after weight reduction suggesting that it is secondary
to a decrease in glucose uptake induced by obesity-associated insulin
resistance.
Source: International Journal of Obesity
(1999)
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