Leptin & Weight Loss
In 1994, a Rockefeller University scientist
identified a mouse gene that makes a protein called leptin. Mice bred
without the leptin-producing gene grew to be grossly obese while those
with higher levels of leptin stayed slim.
The fervent hope was by packaging leptin
in a pill, dieters might finally get the help they need to resist overeating.
But follow-up studies showed that, thanks to genetics or lifestyle patterns,
many overweight people and nearly all obese people tested already have
unusually high levels of leptin in their blood and seem to lose their
sensitivity to it. So leptin boosts proved to be no help.
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