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PYY Weight Loss Hormone
Peripheral Hormone Peptide PYY Affects Appetite and Weight Reduction
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PYY Weight Loss Hormone

Ghrelin appears to have a counterpart - another hormone that sends the opposite signal - telling the brain to hold off the forkfuls.

PYY, which stands for peripheral hormone peptide YY (PYY 3-36), is secreted in the gut and released on a bundle of brain neurons in the hypothalamus that control appetite.

Tests on mice suggest that infusing even small amounts of the hormone into the bloodstream leads to dramatic weight loss. And Bloom and colleagues have shown that tinkering with levels of PYY in people works to suppress appetite.

When his team at Imperial College infused a test group with the hormone they ate a third less food from a free, fancy buffet than people who had received a placebo infusion of saline. Both groups had refrained from eating for a day before the test to ensure they had hearty appetites.

"We need to do further human studies to prove there are no side effects when you take it every day and we need to show it would work in the very overweight," Bloom said. "But right now it's looking like a strong solution."

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