CLA and Weight Regain - Study
The effect of conjugated linoleic acid
supplementation after weight loss on body weight regain, body composition,
and resting metabolic rate in overweight subjects.
CLA & Weight Study - Aim
To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation
in overweight subjects after weight loss on weight regain, body composition,
resting metabolic rate, substrate oxidation, and blood plasma parameters.
CLA & Weight Study - Method
This study had a double-blind, placebo-controlled randomized design. Subjects
were first submitted to a very-low-calorie diet (VLCD) for 3 weeks after
which they started with the 13-week intervention period. They either received
1.8 g CLA or placebo per day (low dosage, LD) or 3.6 g CLA or placebo
per day (high dosage, HD).
CLA & Weight Study - Results
The VLCD significantly lowered body weight, body fat percentage, fat mass,
fat-free mass, resting metabolic rate, respiratory quotient and plasma
glucose, insulin, and triacylglycerol concentrations, while free fatty
acids, glycerol and beta-hydroxy butyrate concentrations were increased.
CLA & Weight Study - Conclusions
The regain of fat-free mass was favorably, dose-independently affected
by a 13-week consumption of 1.8 or 3.6 g CLA/day and consequently increased
the resting metabolic rate. However, it did not result in improved body
weight maintenance after weight loss.
Source: Department of Human Biology, Faculty
of Health Sciences, Maastricht University, The Netherlands.
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