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Protein Diet, Calories and Weight
Effect of High Protein Calorie-Controlled Diet on Weight Loss and Energy Expenditure
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Protein Diet, Calories & Weight - Study

Effect of a high-protein, energy-restricted diet on weight loss and energy expenditure after weight stabilization in hyperinsulinemic subjects.

Protein/Calories Diet Study - Aim
To determine the effect of replacing some dietary carbohydrate with protein, during energy restriction, on weight loss, total energy expenditure (TEE), resting energy expenditure (REE), respiratory quotient (RQ), and the thermic effect of feeding (TEF) in subjects with hyperinsulinemia.

Protein/Calories Diet Study - Method
Parallel, clinical intervention study of 12 weeks energy restriction (6.5 MJ/day) and 4 weeks energy balance (8.2 MJ/day) in two groups of subjects randomly assigned to either a high-protein (HP) diet (27 percent of energy ( percentE) as protein, 45 percentE as carbohydrate) or a lower-protein (LP) diet (16 percentE as protein, 57 percentE as carbohydrate).

Protein/Calories Diet Study - Subjects
A total of 36 obese non-diabetic volunteers with hyperinsulinemia (10 males/26 females, aged 34-65 y, BMI 28-43 kg/m(2), fasting insulin 12-45 mU/l).

Protein/Calories Diet Study - Measurements
Body weight and composition, TEE, REE, and RQ were measured at baseline and at week 16. In addition, the TEF to an HP or LP meal was determined for 3 h, at baseline and at week 16.

Protein/Calories Diet Study - Results
After 16 weeks, weight loss was similar in response to each diet; the overall decrease was 7.9+/-0.6 kg, of which 6.8+/-0.5 kg was fat. REE fell similarly with each diet; the overall decrease was 719+/-106 kJ/day. The TEF was 2 percent greater after the HP than after the LP meal at baseline and 0.8 percent greater at week 16. After 16 weeks, the TEF was not reduced in either dietary group. There was no change in TEE after 16 weeks.

Protein/Calories Diet Study - Conclusion
In subjects with hyperinsulinemia an energy-restrictive diet containing an increased protein-to-carbohydrate ratio does not enhance weight loss or significantly affect energy expenditure. Caloric restriction, rather than the macronutrient composition of the diet, is the most important determinant of weight loss.

Source: Luscombe ND, Clifton PM, Noakes M, Farnsworth E, Wittert G. Department of Physiology, University of Adelaide, South Australia. 2003

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Weight Loss Methods
The science of weight loss and obesity management is constantly evolving, along with research into weight loss drugs, supplements and gastric bypass surgery. At present, however, a balanced diet combined with regular exercise remains the favored weight management strategy of most weight loss experts.

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