Weight Loss & Syndrome X
Impact of weight loss on the metabolic
syndrome X.
Weight Loss Syndrome X Study - Aim
Individuals with the metabolic syndrome X (MS), a clustering of risk factors
[triglycerides, glucose, high-density lipoprotein cholesterol, blood pressure
(BP), abdominal obesity] defined by the National Cholesterol Education
Program (NCEP), are at high risk for coronary heart disease and type 2
diabetes mellitus, and may benefit from aggressive lifestyle modification.
Weight Loss Syndrome X Study - Methods
We reviewed 1 year of consecutive patients' charts to determine the prevalence
of the MS in obese individuals enrolled in a medically supervised rapid
weight loss program, the correlation of weight change with the components
of the MS, and response to diet-induced weight loss.
Weight Loss Syndrome X Study - Results
Out of 185 individuals, 125 (68 percent) met the NCEP definition of the
MS. A moderate decrease in weight (6.5 percent) induced by a very low
calorie diet (VLCD) resulted in substantial reductions of systolic and
diastolic blood pressure (BP), glucose, triglycerides and total cholesterol
at 4 weeks. These improvements were sustained at the end of active weight
loss (average 16.7 weeks; total weight loss 15.1 percent), with further
significant reductions in BP and triglycerides. Weight loss was related
to the changes in each criterion of the metabolic syndrome.
Weight Loss Syndrome X Study - Conclusions
The MS is prevalent in two-thirds of obese individuals enrolling in a
structured weight loss program. Moderate weight loss with a VLCD markedly
improved all aspects of the MS.
Source: Case CC, Jones PH, Nelson K, O'Brian
Smith E, Ballantyne CM. Department of Medicine, Baylor College of Medicine,
Houston. 2002
Weight Loss Methods
The science of weight loss and obesity management is constantly evolving,
along with research into weight loss drugs, supplements and gastric bypass
surgery. At present, however, a balanced diet combined with regular exercise
remains the favored weight management strategy of most weight loss experts. Return to Weight Loss Data
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