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Dexfenfluramine Drug - Weight Loss Effects
Studies in Weight Reduction Effects of Dexfenfluramine
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Dexfenfluramine & Weight Loss

Dexfenfluramine Effects
The long-term effects of dexfenfluramine on the morbidity and mortality associated with obesity have not been established. Short-term (<4 months), placebo-controlled, double-blind studies have provided evidence that dexfenfluramine does not adversely affect glycemia, lipid profile, or blood pressure control in obese patients. Some short-term studies have suggested that weight loss with dexfenfluramine may be associated with a reduction in hyperglycemia in obese diabetic patients, a reduction in blood pressure in obese hypertensive patients, and improvement in the lipid profile in obese hyperlipidemic patients.

Dexfenfluramine & Weight Loss
Dexfenfluramine has been shown to be effective in reducing excess body weight in obese patients. In 16 of 17 double-blind, placebo-controlled trials, of various treatment durations and with different design features, where all patients were on reduced-calorie diets, dexfenfluramine-treated patients lost statistically significantly more weight on average than those treated with placebo. In these studies, weight loss was evident within 4 weeks of initiating treatment, even in some patients where reduced-calorie diet alone had failed to induce a significant weight loss.

In the INDEX study, a one-year, double-blind, placebo-controlled trial of obese patients, dexfenfluramine, in conjunction with a reduced-calorie diet, produced a significant reduction in weight during the first 4 to 6 months. This response was maintained during continuation of therapy (up to 12 months of treatment).

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