Dexfenfluramine & Weight Loss
Dexfenfluramine Effects
The long-term effects of dexfenfluramine on the morbidity and mortality
associated with obesity have not been established. Short-term (<4 months),
placebo-controlled, double-blind studies have provided evidence that dexfenfluramine
does not adversely affect glycemia, lipid profile, or blood pressure control
in obese patients. Some short-term studies have suggested that weight
loss with dexfenfluramine may be associated with a reduction in hyperglycemia
in obese diabetic patients, a reduction in blood pressure in obese hypertensive
patients, and improvement in the lipid profile in obese hyperlipidemic
patients.
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Dexfenfluramine &
Weight Loss
Dexfenfluramine has been shown to be effective in reducing excess
body weight in obese patients. In 16 of 17 double-blind, placebo-controlled
trials, of various treatment durations and with different design features,
where all patients were on reduced-calorie diets, dexfenfluramine-treated
patients lost statistically significantly more weight on average than
those treated with placebo. In these studies, weight loss was evident
within 4 weeks of initiating treatment, even in some patients where
reduced-calorie diet alone had failed to induce a significant weight
loss. |
In the INDEX study, a one-year, double-blind,
placebo-controlled trial of obese patients, dexfenfluramine, in conjunction
with a reduced-calorie diet, produced a significant reduction in weight
during the first 4 to 6 months. This response was maintained during continuation
of therapy (up to 12 months of treatment).
Sources include: www.rxlist.com 2003
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