KB-141 Weight Loss Compound - Short Summary
Researchers associated with Bristol-Myers
Squibb set out to determine whether it was possible to stimulate the metabolism
and thereby reduce body weight, cholesterol and lipoproteins without stimulating
the heart. Their approach was to exploit one of the subtle elements of
thyroid hormone action.
The compound, KB-141, when given to obese
monkeys, caused them to lose 7 percent of their body weight in 7 days
without any change in their diet and with no adverse cardiac effects.
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KB-141 produced significant cholesterol,
lipoprotein (a) and body weight reduction in monkeys with no effect
on heart rate. The research has only just begun so it will be some
years before we know whether KB-141 offers real weight loss benefits
in humans.
Source: Gary J Grover and others,
"Selective thyroid hormone receptor b activation: A strategy
for reduction of weight, cholesterol and lipoprotein with reduced
cardiovascular liability"
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