Weight Loss Information logo

Anti-Obesity Drugs - Orlistat and Sibutramine
Weight Loss and Weight Maintenance Studies of Prescription Pills
Weight Loss Information

Questions About Obesity Medications
Appetite Suppressants - Anti-Obesity Drugs - Prescription Obesity Drugs
Development of Diet Pills - Meridia Short-Term Obesity Drug - Xenical Lipase Inhibitors - Xenical Study
Orlistat & Obesity Management - Orlistat Weight Loss Study - Sibutramine FDA Approved Obesity Drug
Sibutramine Study - Obesity Drugs & Diabetes - Risks of Weight Loss Pills - Adipex Obesity Drug
Side Effects of Adipex - Phentermine to Reduce Appetite - Side Effects of Phentermine


Anti-Obesity Drugs Trial - Orlistat & Sibutramine

Obesity Drugs Trial - Background
Worldwide prevalence rates of obesity and overweight are rising and safe and effective treatment strategies are urgently needed. A number of anti-obesity agents have been studied in short-term clinical trials, but long-term efficacy and safety need to be established.

Obesity Drugs Trial - Aim
To assess/compare the effects and safety of approved anti-obesity medications in clinical trials of at least one-year duration.

Obesity Drugs Trial - Method
Medline, Embase, the Cochrane Controlled Trials Register, the Current Science Meta-register of Controlled Trials, and reference lists of original studies and reviews were searched. Date of last search was December 2002. Drug manufacturers and two obesity experts were contacted in to detect unpublished trials. No language restrictions were imposed.

Obesity Drugs Trial - Selection Criteria

Double-blind, randomised controlled weight loss and weight maintenance trials of approved anti-obesity agents that 1) enrolled adult overweight or obese patients, 2) included a placebo control group or compared two or more anti-obesity drugs 3) used an intention-to-treat analysis, and 4) had a minimum follow-up period of one year.
Abstracts and pseudo-randomised trials were not included.

Obesity Drugs Trial - Data Collection and Analysis
Two reviewers independently assessed all potentially relevant citations for inclusion and methodological quality. The primary outcome measure was weight loss.

Obesity Drugs Trial - Results
Of the eight anti-obesity agents investigated, only orlistat and sibutramine trials met inclusion criteria. Eleven orlistat weight loss studies (four of which reported a second year weight maintenance phase) and five sibutramine studies (three weight loss and two weight maintenance trials) were included. Attrition rates averaged 33 percent during the weight loss phase of orlistat trials and 43 percent in sibutramine studies. All patients received lifestyle modification as a co-intervention. Compared to placebo, orlistat-treated patients lost 2.7 kg or 2.9 percent more weight and patients on sibutramine experienced 4.3 kg or 4.6 percent greater weight loss. The number of patients achieving ten percent or greater weight loss was 12 percent higher with orlistat and 15 percent higher with sibutramine therapy. Weight loss maintenance results were similar. Orlistat caused gastrointestinal side effects and sibutramine was associated with small increases in blood pressure and pulse rate.

Obesity Drugs Trial - Conclusions
Studies evaluating the long-term efficacy of anti-obesity agents are limited to orlistat and sibutramine. Both drugs appear modestly effective in promoting weight loss; however, interpretation is limited by high attrition rates. Longer and more methodologically rigorous studies of anti-obesity drugs that are powered to examine endpoints such as mortality and cardiovascular morbidity are required to fully evaluate any potential benefit of such agents.

Source: Padwal R, Li SK, Lau DCW. Long-term pharmacotherapy for obesity and overweight (Cochrane Methodology Review). In: The Cochrane Library, Issue 4, 2003.

Weight Loss Drugs

ACC2 Weight Loss Enzyme - Appetite Suppressant Drugs - Health Risks Appetite Suppressant - Appetite Suppressants Weight Loss - Axokine Diet Drug - C75 Weight Loss Compound - Cholecystokinin Weight Loss - Dexfenfluramine Weight Loss - Didrex Diet Drugs - Depression Diet Drugs - Diet Drugs Usage - Diet Drugs - Diet Pills Eating Exercise - Diet Pills Weight Regain - Weight Loss Drugs Diet Program - Fen Phen - Fenfluramine Weight Loss Drugs - Fluoxetine Weight Loss - GIP Hormone Weight Loss Drug - Ionamin Diet Drugs - KB-141 Weight Loss Compound - Meridia Diet Drugs - Meridia Weight Loss Drug Ban - New Weight Loss Drugsl - Obesity Drugs Guidelines - Obesity Prescription Drug Markets - Obesity Weight Loss Drugs Treatment - Orlistat Lipase Inhibitor - Orlistat Drug Treatment Obesity - Anti-Obesity Drugs Trial Orlistat & Sibutramine - Orlistat Glucose Study - Orlistat Weight Management Advice - Orlistat Unsatisfactory Weight Reduction - Orlistat / Xenical Pills Weight Reduction - Phentermine Appetite Lowering Diet Drugs - Phentermine Weight Loss Drugs - Phenylpropanolamine (PPA) Weight Loss Drug - Prescription Drugs Treatment of Obesity - Sibutramine Binge Eating - Comparison Sibutramine Dexfenfluramine - Sibutramine Health Safety - Sibutramine Energy Weight Management - Sibutramine Abuse - Sibutramine Weight Loss Trial - Sibutramine Weight Loss Drugs - Tenuate Diet Drugs - Topiramate Anti-Obesity Drug - Weight Loss Drug Therapy - Weight Loss Drugs Review - Weight Loss Medication Candidate Evaluation - Weight Loss Medications Guidelines - Weight Loss Anti-Obesity Drugs - Weight Loss Study Orlistat - Weight Loss Pills Overdose - Minimize Health Risks Weight Loss Pills - Weight Loss Pills Do They Work? - Weight Management Drugs Advice - Zenical Weight Loss Drug

 

Weight Loss Information - Rapid Weight Loss - Diet Program - How to Lose Weight - Best Weight Loss Goals
Weight Loss Advice - Healthy Balanced Diet - Body Fat Percentage - Diets & Weight Loss Programs
Information on Weight Loss Diets - How to Reduce Weight - Weight Management - Weight Loss Surgery Information
Weight Loss Surgery Benefits/Risks - Weight Loss Drugs Advice - Weight Loss Pills / Weight Loss Pills Information
Xenical Weight Loss Drugs - Meridia/Sibutramine Pills - Guide to Diet Pills - Calorie Needs - Weight Loss Supplements
How to Control Weight - Body Mass Index Calculator - Exercise & Fitness to Lose Weight - Weight Health Issues - Obesity
Treatment of Obesity - Advice About Weight Loss - Questions on Weight Loss & Diet - Weight Loss Advice for Women
Weight Loss Advice for Diabetics - Weight Loss Advice for Teenagers - Weight Loss Advice for Adolescents
Diet & Weight Information - Weight Loss Support - Obesity Drug Treatment - Obesity & Gallstones - How to Lower Cholesterol
Dietary Guidelines - Protein, Carbs & Diet - Carbohydrates & Weight Loss - Weight Gain at College
Weight Gain After Quit Smoking - Weight Control in Menopause - Weight Gain in Pregnancy - Weight Control in Pregnancy
Weight Loss Breast-Feeding - Healthy Weight Range - Healthy Weight Loss Diet - Waist Circumference - Weight Cycling
Weight Health Risks - Weight Risks Assessment - Weight Reduction Tips - Weight Loss Guidelines - Weight Loss Products
Weight Loss Tools - Weight Maintenance

Enquiries: Contact Us. See also Terms of Use
© 2003-2017 Weight Loss Information. All Rights Reserved.