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Orlistat/ Xenical Pills for Weight Reduction

Orlistat (Xenical) is a capsule that prevents the absorption of some fat in the intestine. Just under a third of the fat that would otherwise have been absorbed passes straight through the bowel and is excreted in the faeces. As a result it can mean that a person taking orlistat may feel the urgent need to go to the toilet, an increase in the number of times they need to go to the toilet, and when they do go they produce 'fatty stools'. Often they have anal-leakage or oily spotting of their underwear. These effects encourage people taking the drug to limit their fat intake. People taking orlistat may require vitamin supplements because vitamins that are soluble in fat are not properly absorbed when taking orlistat

When treatment with orlistat is offered, arrangements should be made for appropriate health professionals to offer specific concomitant advice, support and counselling on diet, physical activity and behavioural strategies.

Source: NICE Press release: 09 March 2001

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