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Effects of Sibutramine Weight Loss Drugs on Binge Eating, Hunger and Satiety
Sibutramine Reduces Food Intake During Binge-Eating Episodes
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Effects of Sibutramine Weight loss Drugs on Binge Eating, Hunger, and Satiety in a Laboratory Human Feeding Paradigm

Weight Loss Drugs Study Abstract

The purpose of this weight loss drugs study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating.

Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout.

Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine.

Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.

Source: The Neuropsychiatric Research Institute and the University of North Dakota School of Medicine.

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