Weight Loss Information logo

Sibutramine Weight Loss Drug - Health and Safety
Risks and Effectiveness of Meridia Obesity Drug
Weight Loss Information

Questions About Obesity Medications
Appetite Suppressants - Anti-Obesity Drugs - Prescription Obesity Drugs
Development of Diet Pills - Meridia Short-Term Obesity Drug - Xenical Lipase Inhibitors - Xenical Study
Orlistat & Obesity Management - Orlistat Weight Loss Study - Sibutramine FDA Approved Obesity Drug
Sibutramine Study - Obesity Drugs & Diabetes - Risks of Weight Loss Pills - Adipex Obesity Drug
Side Effects of Adipex - Phentermine to Reduce Appetite - Side Effects of Phentermine


Sibutramine Drug - Health & Safety

An assessment of the safety and efficacy of sibutramine, an anti-obesity drug with a novel mechanism of action.

Sibutramine is a combined serotonin(5-HT) and noradrenaline (NA)re-uptake inhibitor. Sibutramine works predominantly through its two pharmacologically active metabolites (i.e. primary and secondary amines) which induce marked weight loss by affecting both food intake and energy expenditure. It is able to enhance the physiological process of satiety, and to stimulate thermogenesis, increasing the efferent sympathetic activity to thermogenically active brown fat. There is a dose-related reduction in body weight in clinical trials with sibutramine, with weight loss up to 11 percent below baseline, which can last up to 18 months with continued treatment. When weight loss is induced with a very low calorie diet (VLCDL), patients randomized to the sibutramine treatment continued to lose weight over a 1 year period, reaching 15 percent below baseline, whereas the placebo-treated patients regained some weight.

Sibutramine improves metabolic fitness, by decreasing the biochemical risk factors associated with obesity, such as plasma triglycerides, total cholesterol and low density lipoprotein (LDL) cholesterol, glucose and insulin, and increasing HDL-cholesterol. In controlled studies, 84 percent of sibutramine-treated patients reported side effects, most commonly including dry mouth, constipation and insomnia, compared with 71 percent of patients receiving placebo. A small increase in heart rate and blood pressure also occurs and persists for as long as treatment is continued, which, therefore, requires monitoring.

Nevertheless, successful treatment of moderately hypertensive obese patients with sibutramine has been demonstrated without undue blood pressure problems and even a mean lowering of blood pressure associated with weight loss. Finally, sibutramine does not have the potential for abuse that is characteristic of amphetamine and it is indistinguishable from placebo in abuse potential studies.

Source: Nisoli E, Carruba MO. Center for Study and Research on Obesity, Department of Preclinical Sciences, School of Medicine, University of Milan, LITA Vialba, L. Sacco Hospital, via G.B. Grassi, 74, Milan 20157, Italy. 2002

Weight Loss Drugs

ACC2 Weight Loss Enzyme - Appetite Suppressant Drugs - Health Risks Appetite Suppressant - Appetite Suppressants Weight Loss - Axokine Diet Drug - C75 Weight Loss Compound - Cholecystokinin Weight Loss - Dexfenfluramine Weight Loss - Didrex Diet Drugs - Depression Diet Drugs - Diet Drugs Usage - Diet Drugs - Diet Pills Eating Exercise - Diet Pills Weight Regain - Weight Loss Drugs Diet Program - Fen Phen - Fenfluramine Weight Loss Drugs - Fluoxetine Weight Loss - GIP Hormone Weight Loss Drug - Ionamin Diet Drugs - KB-141 Weight Loss Compound - Meridia Diet Drugs - Meridia Weight Loss Drug Ban - New Weight Loss Drugsl - Obesity Drugs Guidelines - Obesity Prescription Drug Markets - Obesity Weight Loss Drugs Treatment - Orlistat Lipase Inhibitor - Orlistat Drug Treatment Obesity - Anti-Obesity Drugs Trial Orlistat & Sibutramine - Orlistat Glucose Study - Orlistat Weight Management Advice - Orlistat Unsatisfactory Weight Reduction - Orlistat / Xenical Pills Weight Reduction - Phentermine Appetite Lowering Diet Drugs - Phentermine Weight Loss Drugs - Phenylpropanolamine (PPA) Weight Loss Drug - Prescription Drugs Treatment of Obesity - Sibutramine Binge Eating - Comparison Sibutramine Dexfenfluramine - Sibutramine Health Safety - Sibutramine Energy Weight Management - Sibutramine Abuse - Sibutramine Weight Loss Trial - Sibutramine Weight Loss Drugs - Tenuate Diet Drugs - Topiramate Anti-Obesity Drug - Weight Loss Drug Therapy - Weight Loss Drugs Review - Weight Loss Medication Candidate Evaluation - Weight Loss Medications Guidelines - Weight Loss Anti-Obesity Drugs - Weight Loss Study Orlistat - Weight Loss Pills Overdose - Minimize Health Risks Weight Loss Pills - Weight Loss Pills Do They Work? - Weight Management Drugs Advice - Zenical Weight Loss Drug

 

Weight Loss Information - Rapid Weight Loss - Diet Program - How to Lose Weight - Best Weight Loss Goals
Weight Loss Advice - Healthy Balanced Diet - Body Fat Percentage - Diets & Weight Loss Programs
Information on Weight Loss Diets - How to Reduce Weight - Weight Management - Weight Loss Surgery Information
Weight Loss Surgery Benefits/Risks - Weight Loss Drugs Advice - Weight Loss Pills / Weight Loss Pills Information
Xenical Weight Loss Drugs - Meridia/Sibutramine Pills - Guide to Diet Pills - Calorie Needs - Weight Loss Supplements
How to Control Weight - Body Mass Index Calculator - Exercise & Fitness to Lose Weight - Weight Health Issues - Obesity
Treatment of Obesity - Advice About Weight Loss - Questions on Weight Loss & Diet - Weight Loss Advice for Women
Weight Loss Advice for Diabetics - Weight Loss Advice for Teenagers - Weight Loss Advice for Adolescents
Diet & Weight Information - Weight Loss Support - Obesity Drug Treatment - Obesity & Gallstones - How to Lower Cholesterol
Dietary Guidelines - Protein, Carbs & Diet - Carbohydrates & Weight Loss - Weight Gain at College
Weight Gain After Quit Smoking - Weight Control in Menopause - Weight Gain in Pregnancy - Weight Control in Pregnancy
Weight Loss Breast-Feeding - Healthy Weight Range - Healthy Weight Loss Diet - Waist Circumference - Weight Cycling
Weight Health Risks - Weight Risks Assessment - Weight Reduction Tips - Weight Loss Guidelines - Weight Loss Products
Weight Loss Tools - Weight Maintenance

Enquiries: Contact Us. See also Terms of Use
© 2003-2017 Weight Loss Information. All Rights Reserved.