weight loss information com

Sibutramine, Energy and Weight Management
Effect of Meridia / Sibutramine on Metabolic Rate and Thermogenisis in Obese Women
Advice About Weight Loss

Questions About Obesity Medications
Appetite Suppressants - Anti-Obesity Drugs - Prescription Obesity Drugs
Development of Diet Pills - Meridia Short-Term Obesity Drug - Xenical Lipase Inhibitors - Xenical Study
Orlistat & Obesity Management - Orlistat Weight Loss Study - Sibutramine FDA Approved Obesity Drug
Sibutramine Study - Obesity Drugs & Diabetes - Risks of Weight Loss Pills - Adipex Obesity Drug
Side Effects of Adipex - Phentermine to Reduce Appetite - Side Effects of Phentermine

Sibutramine, Energy & Weight Management

The effect of sibutramine on resting energy expenditure and adrenaline induced thermogenesis in obese females

Sibutramine, an inhibitor of serotonin and noradrenaline uptake, reduces appetite to cause weight loss. This study tested the hypothesis that an increase in energy expenditure also contributes to this weight loss. In addition, the effects of sibutramine on adrenaline induced changes in heart rate and cardiac output were determined.

Nineteen obese females randomly received either sibutramine 15 mg daily or placebo for 12 weeks along with dietary advice. Resting energy expenditure (REE) was measured and then energy expenditure was measured during a 30 min infusion of adrenaline (25 ng/min/kg IBW). Cardiac output and heart rate, measured by Duplex Colour Doppler ultrasonography, were similarly measured in the basal state and post adrenaline. All measurements were recorded at baseline and then after 12 weeks.

Ten patients who received sibutramine reduced their weight by 8.1±3.8 percent while 9 placebo treated subjects reduced their weight by 5.1±4.4 percent.

In absolute terms, REE decreased in placebo subjects from 1500±201 kcal/24 h to 1357±231 kcal/24 h (9.4±9.9 percent) and in sibutramine subjects from 1540±184 kcal/24 h to 1444±128 kcal/24 h (5.3±12.0 percent). The increased weight loss in the sibutramine group was associated with an increase in the FFM adjusted REE (2.2±16.1 percent) unlike the expected decrease (5.8±9.5 percent) in the placebo group. There was some suggestion that the usual positive correlation between loss of weight and decline in REE was lost in the sibutramine group compared with placebo. There was a negative correlation between loss of FFM and decline in REE/kg FFM and which was not evident in placebo. Adrenaline induced energy expenditure was similar in the two groups at the end of the 12 week period and there were no significant cardiovascular changes between the two groups.

Sibutramine limits the decline in REE associated with weight loss, equivalent to about 100 kcal/d. This could allow greater numbers of people to maintain a greater degree of weight loss.

Source: International Journal of Obesity (1999)

Articles About Weight Loss Drugs

  

INFORMATION ABOUT BODY WEIGHT and BODY FAT
Weight Estimate - Healthy Weight Range - Body Weight Composition - Body Fat Guidelines - Healthy Body Fat Percentage - Healthy Waist Circumference
Body Mass Index Calculator - Weight Chart - Weight Loss Tools - Healthy Weight Loss Diet - Healthy Balanced Diet - Calorie Needs to Maintain Weight
Calorie Needs to Lose Weight - Exercise to Lose Weight - Guide to Metabolism
WEIGHT MANAGEMENT and FAT REDUCTION
How to Lose Weight - Fast Weight Loss - Lose Weight and Reduce Fat - Types of Weight Loss Programs - Reviews of Weight Loss Diets - Weight Cycling
Weight Loss Advice - Weight Reduction for Diabetics - Weight Loss for Teenagers - How to Control Weight - Effective Weight Management
How to Maintain Weight - Weight Loss Advice for Women - Weight Control in Pregnancy - Weight Control in Menopause - Weight Loss Questions
DIFFERENT WAYS TO LOSE FAT
Surgery For Weight Loss - Gastrointestinal Surgery - Bariatric Gastric Bypass Surgery - Benefits & Risks of Bariatric Surgery - Guide to Diet Pills
Guide to Weight Loss Drugs - Obesity Drug Treatment - Guide to Weight Loss Pills - Weight Loss Supplements - Healthy Weight Loss Diet Program
Atkins Diet - South Beach Diet - Weight Watchers - Zone Diet - Weight Loss Program
DIETARY HEALTH and DIET SUPPORT
Weight & Health - Weight Loss Guidelines For Adults - Obesity Facts - Obesity Health Risks - Treatment of Obesity - Hypothyroidism Guide
Dietary Guidelines - Types of Diets - Cholesterol Diet - Cholesterol - Weight Loss Support - Weight Management Information - Weight Loss Resources

This site provides general information about how to reduce weight and weight maintenance, featuring articles on a variety of weight-related topics like obesity and overweight, calorie reduction, exercise expenditure, healthy eating plans and dietary nutrition, as well as fat loss, healthy body fat and more. If you are concerned about your weight, for optimum health please talk to your doctor or health care provider before embarking on a new diet, fitness or weight reduction program. © 2005. All Rights Reserved.