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Sibutramine Weight Loss Drugs and Energy Expenditure
Effect of Sibutramine on Metabolic Rate and Thermogenisis
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Sibutramine Weight Loss Drugs & Energy Expenditure

The effect of sibutramine on energy expenditure and appetite during chronic treatment without dietary restriction

The aim was to assess the contribution of a thermogenic effect to weight loss induced by eight weeks treatment with sibutramine (15mg/d) vs placebo in obese subjects. Subjects were thirty-two (7 male, 25 female) healthy obese subjects completed the trial.

Energy expenditure (EE) was measured by indirect calorimetry during a 32 h stay in a respiration chamber before and after 8 weeks treatment. Visual analogue scales were completed for assessment of appetite sensation. No dietary restriction was given.

Sibutramine caused a significant weight loss compared with placebo (-2.4 kg vs+0.3 kg). Despite the larger weight loss after 8 weeks, 24-h EE did not decrease more in the sibutramine than in the placebo group (-2.6 percent vs -2.5 percent). When the changes in 24-h EE were adjusted for changes in body weight, 24-h EE decreased significantly less in the sibutramine group than in the placebo group (0.8 percent vs 3.8 percent). Sibutramine significantly decreased both hunger and anticipated food consumption, and increased satiety scores.

The weight reducing effect of sibutramine in humans is caused by a dual mechanism: reduction of energy intake by increasing satiety and decreasing hunger and prevention of the decline in EE that follows weight loss.

Source: International Journal of Obesity (1999)

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