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Sibutramine and Leptin - Future Obesity Treatment
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Sibutramine & Leptin - Future Obesity Treatment?

Weight Loss Study
A recent weight loss study, examined the combined use of leptin, a recently discovered hormone that is involved in the regulation of food intake, and sibutramine (Meridia ®), an appetite suppressant. When obese rats were given sibutramine in conjunction with small doses of leptin, to prevent the normal decline in circulating leptin that occurs with weight loss, their food intake was lower and their loss of body fat was greater than rats treated with sibutramine alone. This suggests that a reduction in leptin is part of the reason for the "weight plateau" that many people experience while trying to lose weight.

Weight Loss Study Conclusion
The weight loss study suggests new potential approaches for the future use of leptin in treating obesity. However, additional studies are needed to determine whether the synergistic effects of leptin and sibutramine observed in rats also occurs in obese humans.

Source: Press Release: North American Association For The Study Of Obesity

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