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Weight Loss & Weight Loss Drugs - Review

Pharmacotherapeutics - weight loss drugs - can promote modest weight loss and maintenance in obese people. Reports of infrequent, but serious, adverse events (for example, pulmonary hypertension, severe cardiac valvular damage) caused earlier agents (fenfluramine, dexfenfluramine) to be taken off the market and continue to plague some agents that are still available. Worldwide reports of deaths related to the weight loss drug sibutramine prompted Italy to suspend sales and authorities in France, Germany, and England to review the drug. Consumer groups are urging the United States to remove it from the market. Although the weight loss drug orlistat, which blocks fat absorption, has fewer safety concerns, it also has common, annoying, and socially unacceptable side effects, such as faecal incontinence and flatulence. Because of continued concerns about adverse effects and the lack of evidence about long term safety, pharmacological treatments should be used as adjuncts to strategies for changing lifestyle only for selected patients (those with a body mass index and obesity related co-morbidities) after consideration of the trade-off between potential benefits and harms.

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