Obesity and Reproductive Disorders in
Women
Obesity & Ovulation
Obesity, particularly the abdominal phenotype, is associated with several
reproductive disturbances. Whereas mechanisms by which obesity affect
fertility are complex and still not completely understood, obesity may
favor resistance to clomiphene and gonadotrophin-induced ovulation and
reduce outcomes of IVF/ICSI procedures.
Weight Loss Intervention Programs
Due to the beneficial effects of weight loss, lifestyle intervention programs
should represent the first-line approach in the treatment of infertile
obese women. Insulin-sensitizing agents may add further benefits, particularly
if administered in combination with hypo-caloric dieting. Therefore, individualized
pharmacological support aimed at bringing about weight loss and improving
insulin resistance should be widely extended in clinical practice in obese
infertile patients. This may be beneficial even during pregnancy, thereby
permitting favorable physiological delivery and healthy babies.
Source: Oxford University Press 2003
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