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Weight Loss Thyroid Study
Does Weight Reduction Affect Thyroid in Obese Patients
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Does Weight Loss Affect Thyroid in Obese Subjects

Weight Loss Thyroid Study Aim
Can weight loss affect thyroid volume and function in obese subjects?

Weight Loss Thyroid Study Method
The weight loss study used 98 premenopausal euthyroid obese [body mass index (BMI) = 30 kg/m2] women (mean age 40·5 ± 11·4 years) and 31 non-obese (BMI < 25 kg/m2) women (mean age 38·6 ± 12·9 years). Weight, height, BMI, waist circumference, body fat percentage and fat weight of all subjects were measured. Thyroid function and thyroid ultrasonography were performed at baseline and after 6 months of obesity treatment. Subgroup analysis was done according to weight loss.

Weight Loss Thyroid Study Results
Thyroid volume and TSH concentration were higher; free T3 and free T4 concentrations were lower in obese women; however, all were still in the normal range. There was a positive correlation between thyroid volume and body weight, BMI, body fat percentage, body fat weight and waist circumference. There was a positive correlation between TSH concentration and body weight and body fat weight. After 6 months of obesity treatment, thyroid volume and TSH concentration decreased only in obese women who lost > 10 percent body weight. There was a positive correlation between the changes of thyroid volume and the change of body weight and the change of body fat weight

Weight Loss Thyroid Study Conclusion
The weight loss study suggests that thyroid volume and function may vary in obese women in association with body weight and fat mass; over 10 percent weight loss may affect thyroid volume and function, which however, is clinically insignificant.

Source: Blackwell Publishing 2003

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