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Epilepsy Drug With Reduced Calorie Diet May Reduce Obesity
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An epilepsy drug combined with a reduced-calorie diet may result in significant weight loss for obese adults, according to one of several obesity studies in this week's Journal of the American Medical Association.

The epilepsy drug research was prompted by reports of unintentional weight loss in epilepsy patients using zonisamide to prevent seizures.

In the Duke University study, participants who took zonisamide daily for 16 weeks lost an average of nearly 13 pounds, compared with about 2 pounds in patients given dummy pills.

Both groups also ate 500 fewer calories daily in a diet monitored by a dietitian, and were encouraged to increase their activity levels. Patients were mostly women, aged 21 to 50, and weighed over 200 pounds on average.

The study was small - just 60 patients - and the results are preliminary, but they suggest the drug could be a promising addition to efforts to control the nation's obesity epidemic, according to a research team led by Duke's Dr. Kishore Gadde.

The study was funded by Elan Biopharmaceuticals, makers of zonisamide, which is sold under the brand name Zonegran.

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