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Body Mass Index, Weight Change and Fat Levels
Fibrates Lower Cholesterol and Cause Weight Loss
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BMI, Weight Change & Fat Levels

Weight Study Aim
To assess the effects of BMI at baseline and on-treatment weight change on the lipid-lowering efficacy of diet plus fibric acid derivatives (fibrates) in hypercholesterolemic adults.

Weight Study Design
6,003 participants in a Belgian General Practitioners Trial, an open-label, prospective study conducted in a primary care setting.

Weight Study Measures
Effect of initial BMI, on-treatment weight change, or lipid values at baseline on percentage changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Multiple linear regression models, including initial BMI, on-treatment weight change, age, gender, and baseline lipid values, were fitted to control the influences exerted by these variables on each other.

Weight Study Results
Reductions in LDL-C after diet plus fibrate treatment for 12 weeks were inversely related to initial BMI and to TG levels at baseline, and were positively associated with baseline LDL-C concentrations and with on-treatment weight change. Decreases in TG related negatively with initial BMI, and positively with weight loss and TG at baseline. Increases in HDL-C were negatively associated with initial BMI and with baseline TG.

Weight Study Conclusions
The LDL-C lowering efficacy of fibrates is inversely related to initial BMI, and is positively associated with on-treatment weight loss.

Source: Muls E, Van Gaal L, Autier P, Vansant G. Department of Endocrinology, Metabolism and Nutrition, University Hospital Gasthuisberg, Catholic University Leuven, Belgium.1997

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