BMI, Weight Change & Fat Levels
Weight Study Aim
To assess the effects of BMI at baseline and on-treatment weight change
on the lipid-lowering efficacy of diet plus fibric acid derivatives (fibrates)
in hypercholesterolemic adults.
Weight Study Design
6,003 participants in a Belgian General Practitioners Trial, an open-label,
prospective study conducted in a primary care setting.
Weight Study Measures
Effect of initial BMI, on-treatment weight change, or lipid values at
baseline on percentage changes in low-density lipoprotein cholesterol
(LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides
(TG). Multiple linear regression models, including initial BMI, on-treatment
weight change, age, gender, and baseline lipid values, were fitted to
control the influences exerted by these variables on each other.
Weight Study Results
Reductions in LDL-C after diet plus fibrate treatment for 12 weeks were
inversely related to initial BMI and to TG levels at baseline, and were
positively associated with baseline LDL-C concentrations and with on-treatment
weight change. Decreases in TG related negatively with initial BMI, and
positively with weight loss and TG at baseline. Increases in HDL-C were
negatively associated with initial BMI and with baseline TG.
Weight Study Conclusions
The LDL-C lowering efficacy of fibrates is inversely related to initial
BMI, and is positively associated with on-treatment weight loss.
Source: Muls E, Van Gaal L, Autier P, Vansant
G. Department of Endocrinology, Metabolism and Nutrition, University Hospital
Gasthuisberg, Catholic University Leuven, Belgium.1997
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