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Gallstones Formation in Obese Dieters
Effect on Gall Bladder of 2 Low Calorie Diets Differing in Fat Content
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Gallstones Formation in Obese Dieters

The principal aim of this weight loss study was to evaluate the long term effects of two very low calorie diets differing in fat content on gallbladder emptying and gallstone formation in obese subjects.

Weight Loss Study Results
Twenty-two (69 percent) subjects concluded the study, eleven in each group, and a significant weight loss was achieved by all subjects. Gallstones (asymptomatic) developed in 6/11 (54.5 percent) of subjects following the lower fat diet, but in none with the higher fat regimen. In the dieters during the first three months (very low calorie phase) the higher fat meals always induced a significantly greater gallbladder emptying than the lower fat meals. The cholesterol saturation index initially increased significantly and then decreased, without difference between the two groups.

Weight Loss Study Conclusion
In the obese during rapid weight loss from a very low calorie diet, a relatively high fat intake could prevent gallstone formation, probably by maintaining an adequate gallbladder emptying, which could counterbalance lithogenic mechanisms acting during weight loss.

Source: Festi D, Colecchia A, Orsini M, Sangermano A, Sottili S, Simoni P, Mazzella G, Villanova N, Bazzoli F, Lapenna D, Petroni ML, Pavesi S, Neri M, Roda E. Department of Medicine and Aging, University G D'Annunzio Chieti, Italy.

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