Weight Loss Rebound Study
Weight Loss Study Aim
To investigate the possible metabolic factors predisposing to weight gain
subsequent to the cessation of a rapid-weight-loss diet. This was a prospective,
longitudinal, intervention study of a 2 MJ diet daily for 28 d in a metabolic
ward followed by a 12-month outpatient follow-up under a conventional,
hypocaloric diet. Subjects for the weight loss study were thirty-five
females and one male, all with morbid obesity defined by a body mass index
> or = 35 kg/m2. Measurements included VO2 and VCO2 measured by 30
min indirect calorimetry to calculate resting energy expenditure and resting
respiratory quotient at the beginning and end of very-low-calorie diet;
body composition assessed by hydrostatic weighing on day 1; weight recorded
on days 1 and 28 and at follow-up of 3, 6 and 12 months.
Weight Loss Study Results
From among all the variables considered, the resting respiratory quotient
measured on day 28, even adjusted for weight loss during hospitalisation,
was the only one that correlated significantly with the weight changes
recorded during follow-up.
Weight Loss Study Conclusions
Subjects who showed a respiratory quotient on day 28 in the lower range
(< 0.72) were more able to maintain the weight-loss achieved with the
very-low-calorie diet while those in the higher range (> 0.75) were
less able to do so over the follow-up period. Thus, an appropriately measured
respiratory quotient could prove useful in clinical practice as a prognostic
marker of the long-term effectiveness of low- and very-low-calorie diets
used to induce rapid weight loss.
Source: Valtuena S, Salas-Salvado J, Lorda
PG. Human Nutrition Unit, Facultat de Medicina i Ciencies de la Salut,
Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus,
Spain. 1997
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