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Weight Loss Rebound Study
Metabolic Factors Leading to Weight Regain on Cessation of Rapid Weight Loss Diet
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Weight Loss Rebound Study

Weight Loss Study Aim
To investigate the possible metabolic factors predisposing to weight gain subsequent to the cessation of a rapid-weight-loss diet. This was a prospective, longitudinal, intervention study of a 2 MJ diet daily for 28 d in a metabolic ward followed by a 12-month outpatient follow-up under a conventional, hypocaloric diet. Subjects for the weight loss study were thirty-five females and one male, all with morbid obesity defined by a body mass index > or = 35 kg/m2. Measurements included VO2 and VCO2 measured by 30 min indirect calorimetry to calculate resting energy expenditure and resting respiratory quotient at the beginning and end of very-low-calorie diet; body composition assessed by hydrostatic weighing on day 1; weight recorded on days 1 and 28 and at follow-up of 3, 6 and 12 months.

Weight Loss Study Results
From among all the variables considered, the resting respiratory quotient measured on day 28, even adjusted for weight loss during hospitalisation, was the only one that correlated significantly with the weight changes recorded during follow-up.

Weight Loss Study Conclusions
Subjects who showed a respiratory quotient on day 28 in the lower range (< 0.72) were more able to maintain the weight-loss achieved with the very-low-calorie diet while those in the higher range (> 0.75) were less able to do so over the follow-up period. Thus, an appropriately measured respiratory quotient could prove useful in clinical practice as a prognostic marker of the long-term effectiveness of low- and very-low-calorie diets used to induce rapid weight loss.

Source: Valtuena S, Salas-Salvado J, Lorda PG. Human Nutrition Unit, Facultat de Medicina i Ciencies de la Salut, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Spain.

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