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Ghrelin Reduced by Gastric Bariatric Surgery
Weight Loss Gastric Bypass Surgery Reduces Ghrelin Levels in Stomach
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Ghrelin and Gastric Surgery

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Unlike ghrelin levels in the diet group, those in the surgery group did not oscillate in relation to meals. In fact, "ghrelin levels not only failed to rise but dropped profoundly," says Dr. David Cummings, the study's lead researcher and endocrinologist at VA Puget Sound Healthcare System and the University of Washington in Seattle.

Cummings explains the reason for the dramatic difference: The objective of gastric bypass surgery is to shrink the stomach to only 5 percent of its original size by rewiring the course of food through the digestive system. The tiny new stomach pouch can hold only two teaspoons of food, which then travels into the very first part of the small intestine.

It is the presence of ingested food and nutrients that activate the ghrelin cells in the stomach. The permanent absence of food in this organ ultimately suppresses ghrelin production.

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Gastrointestinal weight loss surgery is not an easy weight loss option. It's a serious surgical procedure whose long-term weight loss success depends on a patient's commitment to diet and behavior modification for life, along with exercise for weight control.

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