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Weight, Body Fat and Cancer
Breast Cancer Risk in Post-Menopausal Women Predicted by Rise in Body Fat and Weight Gain
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Weight, Body Fat & Cancer

"During the 5.7 years of follow-up, there were 246 incident breast cancer cases. Weight, height, BMI, and percentBF were positively associated with risk of breast cancer (p-trendless than or equal to0.02). percentBF showed the strongest association, with an RR of 2.01 (95 percent CI 1.26-3.21) in the highest vs. lowest quintile. There was significant modification of this association by hormone use, suggesting a greater impact of body fatness among nonusers. Fat distribution was not independently associated with breast cancer risk. Women with weight gain >21 kg (top quintile) had an RR of 1.75 (95 percent CI 1.11-2.77) compared to women with low weight gain.

"Breast cancer risk in postmenopausal women is predicted by increased body fat and weight gain. percentBF is a more discriminating risk factor for breast cancer incidence than the commonly used BMI," the researchers concluded.

Lahmann and colleagues published the results of their study in International Journal of Cancer (A prospective study of adiposity and postmenopausal breast cancer risk: The Malmo Diet and Cancer Study. Int J Cancer, 2003;103(2):246-252).

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